PICO is a framework that facilitates researchers to identify key components of a clinical issue and develop a specific well-defined research question.
P= Patient or Population or Problem
I = Intervention
C =Comparison
O = Outcome
Intervention: To determine which treatment leads to best patient care
Diagnosis: To determine which test is more accurate in diagnosing a medical condition
Etiology: To determine the risk factors of a medical condition
Prognosis: To determine the clinical course of a medical condition