Clinical uses of glutaraldehydeGlutaraldehyde/2-Hydroxyethylmethacrylate (GLUMA[R]) is a chemical frequently used for desensitization of teeth and has other uses as suggested in the literature. Some newer recommendations have been made relative to its use during tooth preparation, as a disinfectant, rewetting during bonding, prior to cementation of crowns and bridges, and in dealing with pulpal exposures. This article will explore the science behind these and other applications for this chemical and its effect on the tooth structure and its local environment.